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COPD: Human Neutrophil Elastase Lung Hemorrhage Model – Neutrophil Elastase Targets
Neutrophil Elastase plays an important role in the development of chronic obstructive pulmonary disease (COPD), resulting in extensive tissue damage and malfunctioning of the airways.
Administration of human neutrophil elastase induces haemorrhage in the lungs which is measured by an increase in haemoglobin and red blood cells in the BAL.
Administration of human neutrophil elastase induces haemorrhage, this is reversed by administration of the positive control Sivelestat (human NE inhibitor) and AZD9668.
| Study Design | |
|---|---|
| Species/Strain | SD rat |
| Model | Human neutrophil elastase |
| Relevant Use | Assessing the efficacy of novel compounds targeted at neutrophil elastase |
| Readouts Available | BAL Haemoglobin levels, BAL differential cell counts, and BAL cytokines |
Study data generated by Labcorp Huntingdon Pharmacology.
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