Asthma: House Dust mite – Chronic model

Discovery

Chronic exposure to House Dust mite (HDM) is a clinically relevant allergen associated with allergic disorders such as asthma. Chronic HDM exposure induces allergic responses such as AHR, BAL eosinophilia, allergic cytokines and raised systemic IgE as well as histopathological changes and airway remodelling.

Validated positive controls in this model include prednisolone, dexamethasone and roflumilast.

Study Design
Species/Strain	Balb/c mouse
Model	House dust mite (3-5 week model)
Relevant Use	Assessing the efficacy of novel treatments for Asthma
Readouts Available	Lung Function (non-invasive and invasive), AHR assessment, BAL differential cell counts, BAL cytokines, histopathology

Study data generated by Labcorp Huntingdon Pharmacology.

Molecule or Product Type

Biologics, Small Molecule

Models

Mouse

Administration Routes

Dermal, Dietary, Gavage, Implant, Infusion, Inhalation, Intracranial, Intracutaneous, Intramuscular, Intranasal, Intraperitoneal, Intrathecal, Intratracheal, Intravenous, Ocular, Rectal, Subcutaneous, Transcortical, Vaginal

Regulatory

IND & CTA, NDA & BLA, Post-Market

Industry Market

Pharma

Phase

Discovery, Nonclinical

Related Models

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